As we all know, the fight against cancer knows no rest and the researchers analyze, experiment and constantly study the behavior of cancer cells to find a solution to this disease.

A news is about the tumorof the prostate in which Darolutamide, a new non-steroidal molecule, has been shown to have significantly increased metastasis-free survival (MFS) compared to placebo in patients with non-metastatic castration-resistant prostate cancer (nmCRPC).

I also want to mention that prostate cancer is determined by the abnormal proliferation of cells within the prostate gland, which is part of the male reproductive system. It affects mainly men over 50 years of age and the risk increases with age.

Therapeutic options range from surgery to radiation treatment, to therapy using hormone receptor antagonists, substances that block testosterone formation or prevent its effect at its target site. In almost all cases, the tumor develops resistance to conventional hormone treatments. Darolutamide is a non-steroidal receptor antagonist for androgens, with a specific chemical structure that binds the receptor with high affinity and is characterized by a potent antagonist activity, thus inhibiting receptor function and growth of neoplastic cells.

Darolutamide has luckily shown a promising activity in phase 1/2 studies in patients with mCRPC. So the research is making great strides and I hope it will continue in the future to destroy one of the diseases with the highest mortality rate …. and I would not want to sing victory but I read as an article whererecently, some Northwestern University scholars have discovered the cell self-destruct code, finding this that could end the chemotherapy. This code, just as it happens in the processing of software, is contained within each cell and becomes active when they are affected by the tumor and get sick. Going forward in the research, we could develop a treatment based on “suicide” only of cancer cells.

So let’s move on with regards to the treatment of patients with cancer. Such aswe know, in fact, chemotherapy kills sick cells, but not only, thus causing secondary tumors.

Tomas Spies, research coordinator said that now knowing the code, we can trigger the mechanism without having to resort to chemotherapy and without interfering with the genome “!

According to the discovery by researchers at Northwestern University, the self-destruction code is found in a protein that is more than 800,000 years old and has the task of defending the body from cancer. This protein acts on the production of the RNA molecule, which works in close contact with the DNA, and of the micro RNA. Controlling these molecules means controlling anti-cancer weapons. Knowing the code, in fact, it is possible to stop the process that stimulates cell self-destruction and activate the micro RNAs only on the diseased cells.

In addition, this discovery would not have side effects that instead has chemotherapy. Now the next step, as Spies himself explains, is: “Do not find a new toxic substance for cancer, but follow the course of nature, using a mechanism that nature has developed”.

So gentlemen it seems that the tone with which to be able to say that Cancer begins to have more and more weak points thanks to scientific research can increase!

Greetings to all and thanks for reading

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